One of the the classic books about how to successfully play Texas Hold'em is "Hold'em Poker for Advanced Players" by Sklansky and Malmuth. In the book they address heads-up play and seem to advocate a simple tactic that I recommend to beginners, which will often result in stunningly successful results even for players who don't know much about poker or Texas Hold'em.
Specifically, they point out that a player in the small blind can often win simply by raising every hand. In heads-up play, you're not really playing the cards and most of the time your opponent is not going to have a particularly strong hand. So by applying pressure and forcing the big blind to fold - especially when facing a conservative or fearful player - you can consistently win pots with a relatively small investment.
For example, the authors point out that in heads-up hold'em if the blinds are $50 and $100 there is going to be $150 in the pot. If the small blind raises another $150 he has risked $150 to win $150 and, if the big blind folds half the time as would often be expected, the small blind would turn a nice profit. This is especially true when you consider that in addition to stealing several blinds, the small blind can also be expected to win some hands even when the big blind calls.
Consider some basic behavior and odds to see how well this can play out. If the big blind calls a third of time (meaning he's only going to bet out with the top third of his hands), and assuming the big blind wins every one of those hands, he's still losing the $150 in the pot more than two out of three times.
Of course, you might find yourself facing a heads-up opponent utilizing this strategy, in which case you should call more often or re-raise. By doing this, you'll convey the message that it may cost him more than $150 if he raises you every time and minimize the effectiveness of this strategy.
This strategy is particularly effective at lower limit heads-up hold'em tables on the most popular online poker sites.

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